New England has scored a touchdown on 2nd down and the Bills are holding on for a 27-20 lead with 1:22 remaining in the third quarter.
The Patriots offense had a chance to make the game competitive at the start of the second quarter, when rookie tight end Logan Ryan ran a fade route, but he was ruled out with a knee injury.
Instead, Ryan took a handoff on the left side of the formation and threw a touchdown pass to tight end Marlon Mack.
Ryan finished with six catches for 79 yards and a touchdown, but the Pats offense struggled to convert.
Ryan was the third Patriots receiver to score touchdowns this season, joining former NFL quarterback Peyton Manning and his son Eli.
Mack finished with 10 catches for 139 yards and two touchdowns, while Ryan added five catches for 44 yards.
New England’s defense held Buffalo to just 35 yards rushing, and the Pats defense also forced a punt and recovered it at the Buffalo 1-yard line.
The win gave the Patriots an 11-3 record in their past 12 games.